Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Identifieur interne : 000397 ( France/Analysis ); précédent : 000396; suivant : 000398Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Auteurs : Pierre Champy [France] ; Alice Melot [France] ; Vincent Guérineau Eng [France] ; Christophe Gleye [France] ; Djibril Fall [France, Sénégal] ; Gunter U. Höglinger [France] ; Merle Ruberg [France] ; Annie Lannuzel [France] ; Olivier Laprévote [France] ; Alain Laurens [France] ; Reynald Hocquemiller [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Guadeloupe.
English descriptors
- KwdEn :
- Acetogenins, Annona (chemistry), Annona (toxicity), Chromatography, High Pressure Liquid (methods), Fatty Alcohols (adverse effects), Fatty Alcohols (analysis), Fatty Alcohols (chemistry), Guadeloupe, Guadeloupe (epidemiology), Humans, Lactones (adverse effects), Lactones (analysis), Lactones (chemistry), MALDI MS, Mitochondria, Molecular Weight, Nervous system diseases, Neurotoxin, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (etiology), Parkinsonism, Plant Extracts (adverse effects), Plant Extracts (analysis), Plant Extracts (chemistry), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods), acetogenin, annonacin, mitochondria, neurotoxin.
- MESH :
- chemical , adverse effects : Fatty Alcohols, Lactones, Plant Extracts.
- chemical , analysis : Fatty Alcohols, Lactones, Plant Extracts.
- chemical , chemistry : Fatty Alcohols, Lactones, Plant Extracts.
- chemical : Acetogenins.
- geographic , epidemiology : Guadeloupe.
- chemistry : Annona.
- etiology : Parkinsonian Disorders.
- methods : Chromatography, High Pressure Liquid, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization.
- toxicity : Annona.
- Humans, Molecular Weight.
Abstract
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix‐assisted laser desorption‐ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20632
Affiliations:
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Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:regionArea><wicri:noRegion>Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:noRegion><wicri:noRegion>Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:noRegion></affiliation></author><author><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI, Châtenay‐Malabry</wicri:regionArea><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI, Châtenay‐Malabry</wicri:regionArea><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Sénégal</country><wicri:regionArea>Laboratory of Therapeutic Chemistry, Faculté de Pharmacie, Université Cheikh Anta Diop, Dakar</wicri:regionArea><wicri:noRegion>Dakar</wicri:noRegion></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U." last="Höglinger">Gunter U. Höglinger</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Centre Hospitalier Universitaire (CHU) Antilles‐Guyane, Pointe‐à‐Pitre, Guadeloupe</wicri:regionArea><wicri:noRegion>Guadeloupe</wicri:noRegion><wicri:noRegion>Guadeloupe</wicri:noRegion></affiliation></author><author><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprévote">Olivier Laprévote</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:regionArea><wicri:noRegion>Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:noRegion><wicri:noRegion>Centre National de la Recherche Scientifique (CNRS) Gif‐sur‐Yvette</wicri:noRegion></affiliation></author><author><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI, Châtenay‐Malabry</wicri:regionArea><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI, Châtenay‐Malabry</wicri:regionArea><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion><wicri:noRegion>Châtenay‐Malabry</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1629">1629</biblScope><biblScope unit="page" to="1633">1633</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FB83E593BF9464AF001E1B76D87682DF827E9B22</idno><idno type="DOI">10.1002/mds.20632</idno><idno type="ArticleID">MDS20632</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetogenins</term><term>Annona (chemistry)</term><term>Annona (toxicity)</term><term>Chromatography, High Pressure Liquid (methods)</term><term>Fatty Alcohols (adverse effects)</term><term>Fatty Alcohols (analysis)</term><term>Fatty Alcohols (chemistry)</term><term>Guadeloupe</term><term>Guadeloupe (epidemiology)</term><term>Humans</term><term>Lactones (adverse effects)</term><term>Lactones (analysis)</term><term>Lactones (chemistry)</term><term>MALDI MS</term><term>Mitochondria</term><term>Molecular Weight</term><term>Nervous system diseases</term><term>Neurotoxin</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonism</term><term>Plant Extracts (adverse effects)</term><term>Plant Extracts (analysis)</term><term>Plant Extracts (chemistry)</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods)</term><term>acetogenin</term><term>annonacin</term><term>mitochondria</term><term>neurotoxin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acetogenins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Guadeloupe</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Annona</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Annona</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Molecular Weight</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Guadeloupe</term><term>Mitochondrie</term><term>Neurotoxine</term><term>Parkinson maladie</term><term>Parkinsonisme</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Guadeloupe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix‐assisted laser desorption‐ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>Sénégal</li></country><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name></noRegion><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><name sortKey="Guerineau Eng, Vincent" sort="Guerineau Eng, Vincent" uniqKey="Guerineau Eng V" first="Vincent" last="Guérineau Eng">Vincent Guérineau Eng</name><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U." last="Höglinger">Gunter U. Höglinger</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprévote">Olivier Laprévote</name><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></country><country name="Sénégal"><noRegion><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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